PHARMACOLOGICAL PRECONDITIONING. FOCUS ON NICORANDIL
نویسندگان
چکیده
منابع مشابه
Effects of nicorandil preconditioning on membrane dystrophin.
OBJECTIVE Dystrophin is an integral membrane protein that stabilizes the sarcolemmal membrane integrity, and its loss may be involved in the mechanism of ischemia and reperfusion injury. It has been reported that ischemic preconditioning is related to the preservation of membrane dystrophin during ischemia and reperfusion. Preconditioning with nicorandil, a mitochondrial K(ATP) channel opener, ...
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Nicorandil has been shown to induce an infarct-limiting effect similar to that induced by the early phase of ischemic preconditioning (PC). The goals of this study were to determine whether nicorandil induces a delayed cardioprotection that is analogous to the late phase of ischemic PC and, if so, whether nicorandil-induced late PC is associated with upregulation of cardioprotective proteins. C...
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The present study investigated the effects of ischemic preconditioning (IPC) and nicorandil pretreatment on myocardial storage in a donor heart preservation model. Isolated rat hearts were separated into groups: group 1, non-preconditioned control group; group 2, 2.5 min of normothermic ischemia followed by 15 min of normothermic Langendorff perfusion (one IPC cycle); and group 3, 2 cycles of I...
متن کاملBringing preconditioning and postconditioning into focus.
After many years of debate during which the preponderance of opinion was skeptical about the experimental and clinical existence of reperfusion injury (with attitudes ranging between polite condescendence and overt denial), it can be said that the controversy has been now largely resolved, and that the death of cardiomyocytes during reperfusion is now generally admitted as a fact. Perhaps this ...
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One of the most common health problems are diseases of the cardiovascular system with a great bulk of disease burden; while a considerable number of cardiac patients undergo cardiac surgery; cardiac surgical procedures with cardiopulmonary bypass (CPB) are nowadays among the top list of surgical procedures. More than half of a century has passed since the introduction of total cardiopulmonary b...
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ژورنال
عنوان ژورنال: Russian Journal of Cardiology
سال: 2017
ISSN: 1560-4071
DOI: 10.15829/1560-4071-2017-8-114-121